preterm delivery – Lynn Shaffer's Research Essentials

Apr 12 2021

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Preterm Delivery Rates During Coronavirus Lockdown

By Lynnepi

A journal club I attend recently reviewed two articles published in Obstetrics & Gynecology (the “Green journal”) that reported rates of preterm delivery during “lockdowns” imposed last year due to the coronavirus epidemic. One of the articles was from Australia and observed a decrease in preterm births. The paper (https://journals.lww.com/greenjournal/Fulltext/2021/03000/Prematurity_Rates_During_the_Coronavirus_Disease.3.aspx) examined monthly preterm delivery rates…

Jan 27 2020

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Progesterone to Prevent Recurrent Preterm Delivery – How Much Do We Know? (Part 3)

By Lynnepi

Scroll down to the bottom of this post for the essentials. At last we come to a trial which was published within the last year (October 2019), in the American Journal of Perinatology. The present trial, which I’ll refer to as the “confirmatory trial,” was meant to confirm the results of the Meis trial (see…

Jan 20 2020

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Progesterone to Prevent Recurrent Preterm Delivery – How Much Do We Know? (Part 2)

By Lynnepi

Scroll down to the bottom of this post for the essentials. Soon after the da Fonseca trial (Part 1) appeared in the literature, the New England Journal of Medicine published a large randomized clinical trial examining weekly intramuscular injections of 17 alpha-hydroxyprogesterone caproate (17-OHPC) to prevent recurrent preterm delivery. The results of this trial led…

Jan 12 2020

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Progesterone to Prevent Recurrent Preterm Delivery – How Much Do We Know? (Part 1)

By Lynnepi

Spoiler alert: not as much as we should at this point. I was going to write a more straightforward post but I was at an ob/gyn journal club a couple of days ago where we discussed a fairly recent article (Oct 2019) reporting on a randomized controlled trial meant to confirm the positive results of…