Lynn Shaffer's Research Essentials
The essentials for interpreting research and statistics
What It Is In randomized trials, this is preventing people involved in conducting the trial from knowing the sequence of treatment assignments produced by randomization. In other words, when a participant is enrolled it is not known what treatment they will be assigned to. Why It’s Important When investigators and others know the randomization schedule…
Scroll down to the bottom of this post for the essentials. Soon after the da Fonseca trial (Part 1) appeared in the literature, the New England Journal of Medicine published a large randomized clinical trial examining weekly intramuscular injections of 17 alpha-hydroxyprogesterone caproate (17-OHPC) to prevent recurrent preterm delivery. The results of this trial led…