Lynn Shaffer's Research Essentials
The essentials for interpreting research and statistics
Scroll down to the bottom of this post for the essentials. At last we come to a trial which was published within the last year (October 2019), in the American Journal of Perinatology. The present trial, which I’ll refer to as the “confirmatory trial,” was meant to confirm the results of the Meis trial (see…
Scroll down to the bottom of this post for the essentials. Soon after the da Fonseca trial (Part 1) appeared in the literature, the New England Journal of Medicine published a large randomized clinical trial examining weekly intramuscular injections of 17 alpha-hydroxyprogesterone caproate (17-OHPC) to prevent recurrent preterm delivery. The results of this trial led…
Spoiler alert: not as much as we should at this point. I was going to write a more straightforward post but I was at an ob/gyn journal club a couple of days ago where we discussed a fairly recent article (Oct 2019) reporting on a randomized controlled trial meant to confirm the positive results of…
This site is intended for clinicians and others who are planning a research study or who must evaluate a peer-reviewed scientific article to determine whether it will affect their practice. The focus is to inform on the research methodology and statistical concepts that are relevant to these objectives as efficiently as possible. In other words,…